Welcome to depression post three! Previously I covered the symptoms and etiology of depression, and some of the most common antidepressant medications and how they work. Now I’d like to go into some of the research behind it. After all, it’s not like we just grab a depressed person and say “here, take this and call me in the morning”. Every new drug that comes out on the market has to go through rigorous clinical testing to determine whether or not it works, and just as important, whether or not it is safe. And even then, drug companies and the FDA make mistakes.
This post (to save me writing another 2,000 words at a time) is going to focus on the way we study depression (along with other psychiatric disorders) using animal behavioral models, particularly rodent models. But of course, you can’t put a mouse on a couch and ask it how it feels about its mother. What researchers have found is that there are ways of studying the efficacy of traditional antidepressants. So rodent tests for depression are not so much tests for depression so much as they are screening for possible antidepressant therapies. (more…)